Search results for " Overlapping"
showing 7 items of 7 documents
Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profile…
2011
Abstract Gene variants that promote inflammation and cholesterol metabolism have been associated with acute myocardial infarction (AMI) and Alzheimer's disease (AD). We investigated a panel of relevant polymorphisms to distinguish genetic backgrounds for AMI and AD: IL10 -1082G/A, IL6 -174G/C, TNF -308G/A, IFNG +874T/A, SERPINA3 -51G/T, HMGCR -911C/A, APOE e2/3/4 (280 AMI cases, 257 AD cases, and 1307 population controls, all Italian (presumed risk alleles are shown in bold). Six genetic risk sets I to VI were identified by fuzzy latent classification: I had low risk; II and III had low risk before age 65 (II, III); low risk sets lacked pro-inflammatory alleles for HMGCR-TNF-APOE. Pro-infla…
Divergently Transcribed Overlapping Genes Expressed in Liver and Kidney and Located in the 11p15.5 Imprinted Domain
1998
Human chromosomal band 11p15.5 has been shown to contain genes involved in the development of several pediatric and adult tumors and in Beckwith-Wiedemann syndrome (BWS). Overlapping P1 artificial chromosome clones from this region have been used as templates for genomic sequencing in an effort to identify candidate genes for these disorders. PowerBLAST identified several matches with expressed sequence tags (ESTs) from fetal brain and liver cDNA libraries. Northern blot analysis indicated that two of the genes identified by these ESTs encode transcripts of 1-1.5 kb with predominant expression in fetal and adult liver and kidney. With RT-PCR and RACE, full-length transcripts were isolated f…
Transcriptional and Structural Study of a Region of Two Convergent Overlapping Yeast Genes
1999
The exceptionally close packing of many yeast genes and other chromosomal elements raises the question of how those elements are functionally insulated. All published work shows that natural insulators are very effective, but transcriptional interference (TI) occurs if they are mutated or if their natural context is altered. Mechanisms to avoid TI are poorly understood, but are thought to involve an interplay of cis sequences and trans factors in a chromatin context. We have studied the case of two convergent closely packed ORFs (56 bp of separation) in chromosome IX of Saccharomyces cerevisiae. mRNAs from POT1 and YIL161w overlap by up to 115 nt. Convergent transcription causes a small but…
Is Martha Nussbaum really political liberal?
2008
This paper puts under scrutiny Martha Nussbaum’s turn to political liberalism. Unlike Rawls, she seems to assume that overlapping consensus works even within societies without democratic constitutions. Though, this sort of consensus is doomed to be unstable, since there is not a previous constitutional consensus, as Rawls requires. Unlike Rawls’ constructivist theory, her conception of political liberalism is more akin to forms of moral objectivism. Moreover, her allegation of gender discrimination towards institutions that let only men run for certain jobs (such as presidency of certain catholic universities) is based on a clear cut distinction between public and private sphere. However, “…
A statistical analysis of the three-fold evolution of genomic compression through frame overlaps in prokaryotes
2007
Abstract Background Among microbial genomes, genetic information is frequently compressed, exploiting redundancies in the genetic code in order to store information in overlapping genes. We investigate the length, phase and orientation properties of overlap in 58 prokaryotic species evaluating neutral and selective mechanisms of evolution. Results Using a variety of statistical null models we find patterns of compressive coding that can not be explained purely in terms of the selective processes favoring genome minimization or translational coupling. The distribution of overlap lengths follows a fat-tailed distribution, in which a significant proportion of overlaps are in excess of 100 base…
Semi-decentralized strategies in structural vibration control
2011
Published version of an article published in the journal: Modeling, Identification and Control. Also available from the publisher at: http://dx.doi.org/10.4173/mic.2011.2.2 In this work, the main ideas involved in the design of overlapping and multi-overlapping controllers via the Inclusion Principle are discussed and illustrated in the context of the Structural Vibration Control of tall buildings under seismic excitation. A detailed theoretical background on the Inclusion Principle and the design of overlapping controllers is provided. Overlapping and multi-overlapping LQR controllers are designed for a simplied five-story building model. Numerical simulations are conducted to asses the pe…